RT Book, Section
A1 McClanahan, Fabienne
A1 Gribben, John
A2 Kaushansky, Kenneth
A2 Lichtman, Marshall A.
A2 Prchal, Josef T.
A2 Levi, Marcel M.
A2 Press, Oliver W.
A2 Burns, Linda J.
A2 Caligiuri, Michael
SR Print(0)
ID 1121097214
T1 Functions of Tlymphocytes: T-Cell Receptors for Antigen
T2 Williams Hematology, 9e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071833004
LK hemonc.mhmedical.com/content.aspx?aid=1121097214
RD 2024/04/18
AB SUMMARYAll  T  cells  express  a  receptor  for  antigen  that  is  formed  by  two  polymorphic  polypeptides  that  invariably  are  associated  with  a  collection  of  invariant  proteins,  namely  CD3γ,  CD3δ,  CD3ε,  and  CD247.*  These  invariant  proteins  are  necessary  for  surface  expression  and  signaling  by  the  T-cell  receptor.  The  two  polypeptides  that  form  the  T-cell  receptor  on  most  T  cells  are  termed  α  and  β.  A  small  subset  of  T  cells  has  receptors  formed  by  different  polypeptides  termed  γ  and  δ.  The  polypeptides  of  the  T-cell  receptor  have  a  diversity  that  is  comparable  to  that  estimated  for  immunoglobulin  molecules.  However,  unlike  immunoglobulins,  the  T-cell  receptors  recognize  small  fragments  of  antigen  only  if  they  are  presented  to  them  by  defined  major  histocompatibility  complex  molecules  on  the  plasma  membrane  of  another  cell,  the  antigen-presenting  cell.  The  response  of  the  T  cell  to  antigen  depends  on  the  intensity  of  the  signal  generated  by  ligation  of  the  T-cell  receptor,  and  is  modified  by  the  simultaneous  ligation  of  other  accessory  molecules.  Interactions  at  the  contact  sites  between  T-cells  and  antigen-presenting  cells  are  organized  in  the  immunologic  synapse.  The  outcome  of  T-cell  antigen  recognition  can  range  from  immune  activation  and  T-cell  proliferation  to  specific  T-cell  tolerance  and/or  programmed  cell  death.