RT Book, Section
A1 Trinchieri, Giorgio
A1 Childs, Richard W.
A1 Lanier, Lewis L.
A2 Kaushansky, Kenneth
A2 Lichtman, Marshall A.
A2 Prchal, Josef T.
A2 Levi, Marcel M.
A2 Press, Oliver W.
A2 Burns, Linda J.
A2 Caligiuri, Michael
SR Print(0)
ID 1121097265
T1 Functions of Natural Killer Cells
T2 Williams Hematology, 9e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071833004
LK hemonc.mhmedical.com/content.aspx?aid=1121097265
RD 2024/04/20
AB SUMMARYNatural  killer  (NK)  cells,  with  a  predominant  morphology  of  large  granular  lymphocytes,  represent  a  lineage  of  lymphoid  cells  with  constitutive  ability  to  mediate  cytotoxicity  toward  pathologic  target  cells  and  secrete  cytokines.  NK  cells  participate  in  the  innate  resistance  to  microbial  pathogens  and  malignancies;  opposing  effects  of  activating  and  inhibitory  receptors  regulate  NK  cell  activity.  Malignant  expansions  of  NK  cells,  either  acute  or  chronic,  are  rare,  but  represent  well-identified  clinical  entities.