RT Book, Section
A1 MA, Lichtman
A1 MS, Shafer
A1 RE, Felgar
A1 N, Wang
SR Print(0)
ID 1138038931
T1 Leukocyte Alkaline Phosphatase
T2 Lichtman's Atlas of Hematology 2016
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071602679
LK hemonc.mhmedical.com/content.aspx?aid=1138038931
RD 2024/12/07
AB Graphic  Jump  LocationView  Full  Size||Download  Slide  (.ppt)X.K.001Leukocyte  alkaline  phosphatase  stain  of  neutrophils.  Blood  film.  Composite  of  (A)  normal  neutrophils.  Image  shows  the  characteristic  range  of  reaction  strength  of  normal  neutrophils  from  zero  to  about  a  score  of  two  out  of  four.  Characteristically  the  score  of  each  of  100  segmented  and  band  neutrophils  is  summed  to  give  a  total  score  that  might  average  about  80.  (B)  Segmented  and  band  neutrophils  in  chronic  myelogenous  leukemia  in  which  the  neutrophilic  cells  are  very  weakly  positive  or  negative.  In  this  image  the  band  and  segmented  neutrophils  score  zero  out  of  four  and  the  total  score  would  be  very  low,  characteristic  of  chronic  myelogenous  leukemia.  The  availability  of  measurements  of  the  Ph  chromosome  and  BCR-ABL  in  CML  and  other  specific  markers  in  diseases  in  which  the  leukocyte  alkaline  phosphatase  is  altered  has  made  this  measurement  obsolete  in  most  laboratories.  (C)  Reactive  neutrophilia  in  which  the  alkaline  phosphatase  reaction  is  strongly  positive.  These  neutrophils  are  a  score  of  four  out  of  four.  In  such  a  sample,  the  total  score  of  100  neutrophils  counted  would  be  far  above  the  normal  range.