RT Book, Section A1 Karam-Hage, Maher A1 Cinciripini, Paul A2 Duffy, James D. A2 Valentine, Alan D. SR Print(0) ID 1125785352 T1 Nicotine Dependence T2 MD Anderson Manual of Psychosocial Oncology YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071624381 LK hemonc.mhmedical.com/content.aspx?aid=1125785352 RD 2024/04/19 AB In the United States approximately 443,000 deaths in 2007 were attributable to cigarette smoking, according to the Centers for Disease Control and Prevention (CDC). This number makes cigarette smoking the principal cause of premature death and disability in the country.1 In addition, the average annual smoking-attributable health care expenditures nationwide were approximately $96 billion during 2001–2004. Then when combined with productivity losses of $97 billion, the total economic burden of smoking was approximately $193 billion per year.2 Furthermore, the International Agency for Research on Cancer has reported that tobacco smoking is causally linked to 13 types of neoplastic disease.3 Unfortunately, despite tobacco control efforts, including public education about the health hazards of smoking, many smokers continue to encounter extreme difficulty quitting and maintaining long-term abstinence from tobacco.