RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Kipps, Thomas J.
A1 Prchal, Josef T.
A1 Levi, Marcel M.
SR Print(0)
ID 1126651027
T1 Anemia of Chronic Renal Disease
T2 Williams Manual of Hematology, 8e
YR 2011
FD 2011
PB McGraw-Hill Education
PP New York, NY
SN 9780071622424
LK hemonc.mhmedical.com/content.aspx?aid=1126651027
RD 2024/04/20
AB Reduced  production  of  erythropoietin  (EPO)  is  the  most  significant  factor  in  the  development  of  anemia  in  renal  insufficiency.A  modest  reduction  in  red  cell  life  span  occurs  in  uremia,  probably  as  a  result  of  metabolic  impairment  of  red  cells.Iron  deficiency  occurs  from  blood  loss  in  dialysis  tubing,  laboratory  testing,  or  external  bleeding,  sometimes  as  a  result  of  uremia-induced  platelet  dysfunction.  Further,  increased  hepcidin  blocks  iron  absorption  in  the  gut  and  iron  release  from  macrophage  stores  (ameliorated  by  EPO  therapy).The  plasma  volume  varies  widely  in  renal  failure,  with  consequent  variations  in  the  hemoglobin  concentration.