RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Kipps, Thomas J.
A1 Prchal, Josef T.
A1 Levi, Marcel M.
SR Print(0)
ID 1126651599
T1 Microangiopathic Hemolytic Anemia
T2 Williams Manual of Hematology, 8e
YR 2011
FD 2011
PB McGraw-Hill Education
PP New York, NY
SN 9780071622424
LK hemonc.mhmedical.com/content.aspx?aid=1126651599
RD 2024/04/19
AB Intravascular  hemolysis  caused  by  fragmentation  of  normal  red  cells  passing  through  abnormal  arterioles  and  other  small  vessels.The  hemolytic  anemia  generated  by  red  cell  damage  in  small  vessels  is  referred  to  as  microangiopathic  hemolytic  anemia,  a  type  of  fragmentation  hemolytic  anemia."Split"  red  cells  of  varying  shapes,  referred  to  as  schistocytes,  are  prominent  on  blood  films.Less-extensive  red  cell  fragmentation,  development  of  schistocytes,  and  hemolysis  may  also  occur  under  conditions  of  more  moderate  vascular  occlusion  or  endothelial  surface  abnormalities,  sometimes  under  conditions  of  lower  shear  stress.Excessive  platelet  aggregation,  fibrin  polymer  formation,  and  secondary  fibrinolysis  in  the  arterial  or  venous  microcirculation  are  seen  in  disseminated  intravascular  coagulation  (see  Chap.  86),  preeclampsia,  giant  cavernous  hemangiomas  (the  Kasabach-Merritt  phenomenon),  or  in  the  HELLP  (hemolysis  elevated  liver  enzyme  and  low  platelets)  syndrome.