RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Kipps, Thomas J.
A1 Prchal, Josef T.
A1 Levi, Marcel M.
SR Print(0)
ID 1126651690
T1 Hemolytic Anemia Resulting from Warm-Reacting Antibodies
T2 Williams Manual of Hematology, 8e
YR 2011
FD 2011
PB McGraw-Hill Education
PP New York, NY
SN 9780071622424
LK hemonc.mhmedical.com/content.aspx?aid=1126651690
RD 2024/09/16
AB In  autoimmune  hemolytic  anemia  (AHA),  shortened  red  blood  cell  (RBC)  survival  is  the  result  of  host  antibodies  that  react  with  autologous  RBC.AHA  may  be  classified  by  whether  an  underlying  disease  is  present  (secondary)  or  not  (primary  or  idiopathic)  (Table  24–1).AHA  may  also  be  classified  by  the  nature  of  the  antibody  (Table  24–2)."Warm-reacting"  antibodies  are  usually  of  the  IgG  type,  have  optimal  activity  at  37°C,  and  bind  complement."Cold-reacting"  antibodies  show  affinity  at  lower  temperatures  (see  Chap.  25).Occasionally,  mixed  disorders  occur  with  both  warm  and  cold  antibodies.Warm  antibody  AHA  is  the  most  common  type.