RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Kipps, Thomas J.
A1 Prchal, Josef T.
A1 Levi, Marcel M.
SR Print(0)
ID 1126652182
T1 Basophils and Mast Cells and Their Diseases
T2 Williams Manual of Hematology, 8e
YR 2011
FD 2011
PB McGraw-Hill Education
PP New York, NY
SN 9780071622424
LK hemonc.mhmedical.com/content.aspx?aid=1126652182
RD 2024/04/18
AB Normal  basophil  count  is  0.015  to  0.08  ×  109/L.The  causes  of  basophilia  are  listed  in  Table  35–1.An  increase  in  the  absolute  basophil  count  among  other  blood  cell  abnormalities  may  be  a  useful  sign  of  a  chronic  clonal  myeloid  disease  (see  Table  35–1).In  chronic  myelogenous  leukemia  (CML),  an  increased  absolute  basophil  count  occurs  in  virtually  all  patients.De  novo  acute  basophilic  leukemia  is  very  rare,  but  marrow  basophilia  may  be  associated  uncommonly  with  other  subtypes  of  acute  myelogenous  or  acute  promyelocytic  leukemia  (see  Table  35–2).Basophils  in  acute  or  chronic  clonal  myeloid  diseases  are  derived  from  the  malignant  clone  and  occasionally  may  cause  symptoms  of  histamine  release  (flushing,  pruritus,  hypotension)  or  severe  peptic  ulcer  disease  reflecting  hypersecretion  of  gastric  acid  and  pepsin.