RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Kipps, Thomas J.
A1 Prchal, Josef T.
A1 Levi, Marcel M.
SR Print(0)
ID 1126652211
T1 Monocytosis and Monocytopenia
T2 Williams Manual of Hematology, 8e
YR 2011
FD 2011
PB McGraw-Hill Education
PP New York, NY
SN 9780071622424
LK hemonc.mhmedical.com/content.aspx?aid=1126652211
RD 2024/04/19
AB Monocytes  in  the  blood  are  in  transit.  They  function  in  the  tissues,  where  they  mature  into  macrophages  and  participate  in:—  Inflammation,  including  granulomatous  reactions,  atheroma  formation,  and  tissue  repair.—  Immunologic  reactions,  including  delayed  hypersensitivity.—  Reactions  to  neoplasia  and  allografts.The  need  for  macrophages  in  tissues  also  can  be  met  by  local  proliferation  of  macrophages,  not  requiring  increased  transit  of  blood  monocytes.Ninety  percent  of  blood  monocytes  intensely  express  CD14  (lipopolysaccharide  receptor)  but  not  CD16  and  10  percent  have  weak  expression  of  CD14  and  strongly  express  CD16.Older  persons  have  a  striking  decrease  in  the  proportion  of  CD14+CD16–  to  CD14+CD16+  monocytes  compared  with  younger  persons.Disorders  rarely  produce  abnormalities  of  monocytes  alone  in  the  absence  of  other  blood  cell  abnormalities.