RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Kipps, Thomas J.
A1 Prchal, Josef T.
A1 Levi, Marcel M.
SR Print(0)
ID 1126652805
T1 The Chronic Myelogenous Leukemias
T2 Williams Manual of Hematology, 8e
YR 2011
FD 2011
PB McGraw-Hill Education
PP New York, NY
SN 9780071622424
LK hemonc.mhmedical.com/content.aspx?aid=1126652805
RD 2024/04/19
AB BCR-ABL-positive  chronic  myelogenous  leukemia  (CML)  results  from  a  somatic  mutation  in  a  pluripotential  lymphohematopoietic  cell.CML  is  characterized  by  granulocytic  leukocytosis,  granulocytic  immaturity,  basophilia,  anemia,  and  often  thrombocytosis  in  the  blood,  intense  leukemic  granulocytic  precursor  expansion  in  the  marrow,  and  splenomegaly.The  natural  history  of  the  disease  is  to  evolve  into  an  accelerated  phase  in  which  cytopenias  develop  and  response  to  chronic  phase  therapy  is  lost;  it  often  terminates  in  acute  leukemia.