RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Kipps, Thomas J.
A1 Prchal, Josef T.
A1 Levi, Marcel M.
SR Print(0)
ID 1126652851
T1 Primary Myelofibrosis
T2 Williams Manual of Hematology, 8e
YR 2011
FD 2011
PB McGraw-Hill Education
PP New York, NY
SN 9780071622424
LK hemonc.mhmedical.com/content.aspx?aid=1126652851
RD 2024/04/25
AB Primary  myelofibrosis  is  a  chronic  clonal  myeloid  disorder  that  originates  in  mutations  in  a  multipotential  hematopoietic  cell.  The  disease  is  characterized  by  (a)  anemia,  (b)  splenomegaly,  (c)  increased  CD34+  cells,  immature  granulocytes,  erythroid  precursors,  and  teardrop-shaped  red  cells  in  the  blood,  (d)  marrow  fibrosis  and  increased  dysmorphic  megakaryocytes,  and  (e)  osteosclerosis.