RT Book, Section A1 Lichtman, Marshall A. A1 Kaushansky, Kenneth A1 Kipps, Thomas J. A1 Prchal, Josef T. A1 Levi, Marcel M. SR Print(0) ID 1126653505 T1 The Chronic Lymphocytic Leukemias T2 Williams Manual of Hematology, 8e YR 2011 FD 2011 PB McGraw-Hill Education PP New York, NY SN 9780071622424 LK hemonc.mhmedical.com/content.aspx?aid=1126653505 RD 2024/03/29 AB Chronic lymphocytic leukemia (CLL) is a neoplastic disease characterized by accumulation of small, mature-appearing lymphocytes in blood, marrow, and lymphoid tissues.The most prevalent adult leukemia in western societies.The age-adjusted incidence rate for CLL in the United States is 4.2/100,000 persons according to the Surveillance Epidemiology and End-Result Program of the National Cancer Institute.The age-adjusted incidence rate of CLL worldwide is 2.5/100,000 persons as determined by the International Agency for Research on Cancer of the World Health Organization.In 98 percent of patients, the disease is of B-cell lineage; less than 2 percent of patients have T-cell lineage leukemia.Approximately 0.8 percent of all cancers and approximately 30 percent of all leukemias annually.CLL is very uncommon in Eastern Asia (e.g., Japan and Korea).