RT Book, Section A1 Lichtman, Marshall A. A1 Kaushansky, Kenneth A1 Kipps, Thomas J. A1 Prchal, Josef T. A1 Levi, Marcel M. SR Print(0) ID 1126654750 T1 Hemostatic Dysfunction Related to Liver Diseases T2 Williams Manual of Hematology, 8e YR 2011 FD 2011 PB McGraw-Hill Education PP New York, NY SN 9780071622424 LK hemonc.mhmedical.com/content.aspx?aid=1126654750 RD 2024/10/13 AB Loss of hepatic parenchymal cells leads to decreased plasma levels of all plasma coagulation factors except factor VIII and von Willebrand factor.Thrombocytopenia occurs frequently and is usually a result of splenic sequestration (see Chap. 74), but may also be caused by an autoimmune mechanism, disseminated intravascular coagulation (DIC), folic acid deficiency, and decreased platelet production. In some patients, thrombocytopenia due to thrombopoietin (TPO) deficiency and platelet dysfunction contribute to the hemostatic abnormalities.Enhanced fibrinolysis is common, and appears to be caused by complex pathogenetic mechanisms, including release and impaired clearance of plasminogen activators.Dysfibrinogenemia is relatively frequently found in patients with chronic liver disease.Patients with chronic liver disease may develop DIC.