RT Book, Section A1 Lichtman, Marshall A. A1 Kaushansky, Kenneth A1 Kipps, Thomas J. A1 Prchal, Josef T. A1 Levi, Marcel M. SR Print(0) ID 1126654795 T1 Disseminated Intravascular Coagulation T2 Williams Manual of Hematology, 8e YR 2011 FD 2011 PB McGraw-Hill Education PP New York, NY SN 9780071622424 LK hemonc.mhmedical.com/content.aspx?aid=1126654795 RD 2024/03/28 AB Disseminated intravascular coagulation (DIC) is a syndrome that is characterized by systemic intravascular activation of coagulation, leading to fibrin deposition in the microvasculature and small-midsize vessels, thereby contributing to organ dysfunction. Simultaneously, ongoing consumption of platelets and coagulation factors lead to thrombocytopenia and impaired coagulation and may result in serious bleeding complications.DIC never occurs by itself but is always secondary to an underlying cause. Table 86–1 lists the most frequently occurring disorders know to be associated with DIC.