RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Kipps, Thomas J.
A1 Prchal, Josef T.
A1 Levi, Marcel M.
SR Print(0)
ID 1126654961
T1 Hereditary Thrombophilia
T2 Williams Manual of Hematology, 8e
YR 2011
FD 2011
PB McGraw-Hill Education
PP New York, NY
SN 9780071622424
LK hemonc.mhmedical.com/content.aspx?aid=1126654961
RD 2024/04/19
AB Risk  factors  for  thromboembolism  may  be  genetic  and  acquired  (Table  89–1).Hereditary  thrombophilia  is  a  genetically  determined  increased  risk  of  thrombosis.Up  to  50  percent  of  patients  presenting  with  a  first  deep  venous  thrombosis  will  have  an  abnormal  laboratory  test  suggesting  a  thrombophilic  defect,  and  patients  with  recurrent  thromboses  or  with  a  strong  family  history  are  even  more  likely  to  have  laboratory  evidence  of  a  thrombophilic  state  (Table  89–2).Up  to  16  percent  of  patients  with  thrombophilia  have  inherited  more  than  one  abnormality.These  inherited  defects  also  interact  frequently  with  acquired  risk  factors,  such  as  inactivity,  trauma,  malignancy,  or  oral  contraceptive  use,  to  lead  to  clinical  thrombosis.