RT Book, Section A1 Chihara, Dai A1 Wang, Casey A1 Duvic, Madeleine A1 Medeiros, L. Jeffrey A1 Oki, Yasuhiro A2 Kantarjian, Hagop M. A2 Wolff, Robert A. SR Print(0) ID 1126740719 T1 T-Cell Lymphomas T2 The MD Anderson Manual of Medical Oncology, 3e YR 2016 FD 2016 PB McGraw-Hill Medical PP New York, NY SN 9780071847940 LK hemonc.mhmedical.com/content.aspx?aid=1126740719 RD 2024/10/07 AB Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of lymphomas derived from a mature T cell (Fig. 9-1). Currently, the World Health Organization (WHO) classification combines mature T- and natural killer (NK)-cell neoplasms under the umbrella term PTCL, and the category is composed of 23 different entities (Table 9-1), based on the different morphologic, phenotypic, molecular, and clinical features, including disease site (1). Most PTCLs lack distinct genetic or biologic alterations that are seen in B-cell lymphomas, such as t(14;18) in follicular lymphoma and t(11;14) in mantle cell lymphoma. Compared with B-cell lymphomas, many types of PTCL develop not in lymph nodes, but in specific extranodal sites such as extranodal NK/T-cell lymphoma, nasal type (ENKL) in the nasal cavity, enteropathy-associated T-cell lymphoma (EATL) in the small intestine, and hepatosplenic T-cell lymphoma (HSTL) in the liver and spleen.