RT Book, Section
A1 Cairns, Rob A.
A1 Tannock, Ian F.
A1 Wouters, Bradly
A2 Tannock, Ian F.
A2 Hill, Richard P.
A2 Bristow, Robert G.
A2 Harrington, Lea
SR Print(0)
ID 1127472594
T1 Tumor Growth, Microenvironment, and Metabolism
T2 The Basic Science of Oncology, 5e
YR 2016
FD 2016
PB McGraw-Hill Education Medical
PP New York, NY
SN 9780071745208
LK hemonc.mhmedical.com/content.aspx?aid=1127472594
RD 2024/04/23
AB Tumors  grow  because  the  homeostatic  mechanisms  that  maintain  the  appropriate  number  of  cells  in  normal  tissues  are  defective,  leading  to  an  imbalance  between  cell  proliferation  and  cell  death  and  to  expansion  of  the  cell  population.  The  use  of  autoradiography  with  tritiated  thymidine  in  the  1950s  and  1960s,  and  the  subsequent  application  of  flow  cytometry,  have  allowed  a  detailed  analysis  of  tumor  growth  in  terms  of  the  kinetics  of  proliferation  of  the  constituent  cells.  The  proliferative  rate  of  tumor  cells  varies  widely  between  tumors;  slowly  proliferating  or  nonproliferating  cells  are  common,  and  there  is  often  a  high  rate  of  cell  death.  Several  normal  tissues,  including  bone  marrow  and  intestine,  contain  cells  with  high  rates  of  proliferation,  and  damage  to  these  cells  is  often  dose-limiting  for  chemotherapy.  The  rate  of  cell  proliferation  in  tumors  may  be  an  important  factor  in  determining  prognosis  and  response  to  therapy.