RT Book, Section
A1 Hilal-Dandan, Randa
A1 Brunton, Laurence L.
SR Print(0)
ID 1127547829
T1 Muscarinic Receptor Agonists and Antagonists
T2 Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071769174
LK hemonc.mhmedical.com/content.aspx?aid=1127547829
RD 2024/10/09
AB Muscarinic  acetylcholine  receptors  in  the  peripheral  nervous  system  occur  primarily  on  autonomic  effector  cells  innervated  by  postganglionic  parasympathetic  nerves.  Muscarinic  receptors  are  also  present  in  autonomic  ganglia  and  on  some  cells  (e.g.,  vascular  endothelial  cells)  that,  paradoxically,  receive  little  or  no  cholinergic  innervation.  Within  the  CNS,  the  hippocampus,  cortex,  and  thalamus  have  high  densities  of  muscarinic  receptors.  Acetylcholine  (ACh),  the  naturally  occurring  neurotransmitter  for  these  receptors,  has  virtually  no  systemic  therapeutic  applications  because  its  actions  are  diffuse,  and  its  hydrolysis,  catalyzed  by  both  acetylcholinesterase  (AChE)  and  plasma  butyrylcholinesterase,  is  rapid.  Muscarinic  agonists  mimic  the  effects  of  ACh  at  these  sites  and  are  longer-acting  congeners  of  ACh  or  natural  alkaloids.