RT Book, Section A1 Chabner, Bruce A. A2 Chabner, Bruce A. A2 Longo, Dan L. SR Print(0) ID 1127646562 T1 Natural Products: Bleomycin and Trabectedin T2 Harrison's Manual of Oncology, 2e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071793254 LK hemonc.mhmedical.com/content.aspx?aid=1127646562 RD 2024/03/28 AB Natural product research has yielded many active anticancer compounds acting as inhibitors of topoisomerases (Chapter 4) and as antimitotics (Chapter 4). Others, such as bleomycin and trabectedin, interact directly with DNA and exhibit unusual mechanisms of action.