RT Book, Section A1 Chabner, Bruce A. A2 Chabner, Bruce A. A2 Longo, Dan L. SR Print(0) ID 1127646836 T1 Antiandrogen Therapy T2 Harrison's Manual of Oncology, 2e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071793254 LK hemonc.mhmedical.com/content.aspx?aid=1127646836 RD 2024/10/09 AB The initial attempt at treating cancer with hormone ablation was implemented by Charles Huggins at the University of Chicago in 194l, when he hypothesized that the prostate depended on testosterone (and, ultimately, its metabolite dihydrotestosterone) for its growth (1). Orchiectomy of patients with advanced prostate cancer reduced serum testosterone to barely detectable levels (less than 50 ng/dl) and produced dramatic relief of bone pain in 90% of such patients. The median duration of response was about 1 year, and hormone-independent tumor emerged in most cases. Huggins was awarded a Nobel Prize for his work.