RT Book, Section
A1 Longo, Dan L.
A2 Chabner, Bruce A.
A2 Longo, Dan L.
SR Print(0)
ID 1127646959
T1 Cytokines, Growth Factors, and Immune-Based Interventions
T2 Harrison's Manual of Oncology, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071793254
LK hemonc.mhmedical.com/content.aspx?aid=1127646959
RD 2024/04/18
AB Cytokines  are  soluble  proteins  or  glycoproteins  that  exert  trophic  effects  on  a  variety  of  targets  based  on  the  expression  of  particular  ligand-specific  receptors  on  the  target.  All  of  the  cytokines  have  not  yet  been  identified;  but  at  this  time,  more  than  80  different  molecules  have  been  defined.  The  same  cytokine  can  exert  different  effects  on  different  cells  and  tissues.  However,  the  biochemical  consequences  within  the  cell  of  ligand  binding  to  its  cellular  receptor  are  similar  among  all  the  targets.  A  number  of  cytokines  have  been  evaluated  for  their  antitumor  effects  including  the  interferons,  interleukin-1  (IL1),  tumor  necrosis  factor,  IL4,  IL12,  and  others.  The  rationale  for  testing  these  agents  as  antitumor  agents  is  twofold.  First,  many  of  these  agents  stimulate  cells  of  the  immune  system,  an  effect  that  could  promote  the  immunological  killing  of  the  tumor  cells.  Second,  many  neoplastic  cells  retain  the  cytokine  receptors  of  their  normal  counterparts;  thus,  direct  biological  and  potentially  antitumor  effects  are  theoretically  possible.