RT Book, Section
A1 Longo, Dan L.
A2 Chabner, Bruce A.
A2 Longo, Dan L.
SR Print(0)
ID 1127647053
T1 Monoclonal Antibodies in Cancer Treatment
T2 Harrison's Manual of Oncology, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071793254
LK hemonc.mhmedical.com/content.aspx?aid=1127647053
RD 2024/04/24
AB Monoclonal  antibodies  are  used  in  five  different  ways  in  the  treatment  of  human  conditions.  First,  antibodies  have  a  variety  of  effector  mechanisms  that  focus  an  array  of  immunologic  agents  (complement,  various  effector  cells)  on  the  target  to  which  they  bind.  Second,  antibodies  can  serve  as  targeting  moieties  to  specifically  deliver  diverse  killing  or  inhibitory  molecules  to  a  specific  site.  Third,  antibodies  can  be  directed  at  soluble  protein  or  proteoglycan  hormones  or  cytokines  or  their  receptors  to  antagonize  a  particular  function  such  as  cell  growth,  invasion,  or  migration.  Fourth,  antibodies  can  be  used  as  antigens  to  elicit  antitumor  responses  against  immunoglobulin-expressing  tumors.  Fifth,  antibodies  can  be  used  to  alter  the  pharmacologic  behavior  of  other  substances  to  either  increase  or  decrease  their  half-life  or  alter  their  distribution  (e.g.,  antibodies  to  digoxin  used  to  treat  digoxin  toxicity).