RT Book, Section
A1 Carpenter, Stephen M.
A1 Vianello, Fabrizio
A1 Poznansky, Mark C.
A2 Chabner, Bruce A.
A2 Longo, Dan L.
SR Print(0)
ID 1127647151
T1 Febrile Neutropenia
T2 Harrison's Manual of Oncology, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071793254
LK hemonc.mhmedical.com/content.aspx?aid=1127647151
RD 2024/04/24
AB Immune-compromised  state  refers  to  a  change  of  the  host  defense  systems  that  confer  an  increased  susceptibility  to  infection.  Neutropenia  remains  the  major  defect  of  the  defense  systems  predisposing  to  severe  infections.  Fever  in  a  neutropenic  patient  should  be  considered  a  medical  emergency  as  it  has  been  demonstrated  that  a  delay  in  specific  therapy  is  associated  with  up  to  a  70%  mortality  rate  (1).  In  this  chapter,  we  present  the  medical  approach  to  fever  in  neutropenic  patients  by  analyzing  the  predisposing  factors,  pathogenesis,  diagnosis,  and  treatment.