RT Book, Section
A1 Tothova, Zuzana
A1 Bradner, James
A2 Chabner, Bruce A.
A2 Longo, Dan L.
SR Print(0)
ID 1127647188
T1 Anemia
T2 Harrison's Manual of Oncology, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071793254
LK hemonc.mhmedical.com/content.aspx?aid=1127647188
RD 2024/04/19
AB Anemia  is  defined  as  a  decrease  in  the  red  blood  cell  mass  circulating  in  the  bloodstream,  and  derives  from  an  imbalance  in  the  production  and  loss  of  erythrocytes.  Symptoms  and  signs  associated  with  anemia  result  from  impaired  oxygen  delivery  to  the  tissues.  Common  symptoms  include  fatigue,  malaise,  weakness,  dyspnea  on  exertion,  palpitations,  and  chest  pressure.  Patients  may  manifest  additional  overt  signs  such  as  pallor,  tachycardia,  impaired  mentation,  high-output  congestive  heart  failure,  shock,  and  death.  The  1968  World  Health  Organization  (WHO)  criteria  define  anemia  as  hemoglobin  less  than  12  g/dl  in  women  and  hemoglobin  less  than  13  g/dl  in  men.  The  current  working  definition  of  anemia  is  a  hemoglobin  level  that  is  two  standard  deviations  below  the  mean  hemoglobin  level  for  a  given  sex  and  age.