RT Book, Section
A1 Rosovsky, Rachel P.G.
A2 Chabner, Bruce A.
A2 Longo, Dan L.
SR Print(0)
ID 1127647294
T1 Cancer and Coagulopathy
T2 Harrison's Manual of Oncology, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071793254
LK hemonc.mhmedical.com/content.aspx?aid=1127647294
RD 2024/04/23
AB The  association  between  cancer  and  thrombosis  was  first  proposed  by  Armand  Trousseau  (Figure  19-1)  when  he  recognized  the  condition  of  thrombophlebitis  migrans,  as  a  forewarning  of  occult  malignancy  (1).  In  1865,  he  remarked,  "Should  you,  when  in  doubt  as  to  the  nature  of  an  affection  of  the  stomach,  should  you  when  hesitating  between  chronic  gastritis,  simple  ulcer,  and  cancer,  observe  a  vein  become  infected  in  the  arm  or  leg,  you  may  dispel  your  doubt,  and  pronounce  in  a  positive  manner  that  there  is  a  cancer  …"  (1).  Although  the  association  of  hemostatic  disorders  and  cancer  has  been  studied  extensively  over  the  past  100  years,  venous  thromboembolism  (VTE),  defined  herein  as  pulmonary  embolus  (PE)  or  deep  vein  thrombosis  (DVT),  remains  a  major  cause  of  morbidity  and  mortality  in  cancer  patients.