RT Book, Section
A1 Raje, Noopur
A1 Longo, Dan L.
A2 Chabner, Bruce A.
A2 Longo, Dan L.
SR Print(0)
ID 1127648027
T1 Plasma Cell Disorders
T2 Harrison's Manual of Oncology, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071793254
LK hemonc.mhmedical.com/content.aspx?aid=1127648027
RD 2024/04/24
AB Plasma  cell  disorders  are  a  group  of  related  diseases  arising  from  a  common  progenitor  belonging  to  the  B-cell  lineage.  They  are  characterized  by  the  expansion  of  plasma  cells  in  the  bone  marrow  (BM)  and  nearly  always  accompanied  by  the  presence  of  a  monoclonal  immunoglobulin  (Ig)  or  Ig  fragment  in  the  serum  and/or  urine  of  patients  (1).  Monoclonal  gammopathy  of  undetermined  significance  (MGUS),  multiple  myeloma  (MM),  Waldenstrom's  macroglobulinemia  (WM),  primary  amyloidosis,  and  heavy  chain  diseases  (HCD)  all  belong  to  this  group  of  disorders.  Dysproteinemias  or  plasma  cell  dyscrasias  are  some  of  the  other  terms  used  to  refer  to  this  unique  group  of  disorders.