RT Book, Section
A1 Hillman, Robert S.
A1 Ault, Kenneth A.
A1 Leporrier, Michel
A1 Rinder, Henry M.
SR Print(0)
ID 1127765053
T1 NORMAL ERYTHROPOIESIS
T2 Hematology in Clinical Practice, 5e
YR 2016
FD 2016
PB McGraw-Hill Medical
PP New York, NY
SN 9780071626996
LK hemonc.mhmedical.com/content.aspx?aid=1127765053
RD 2024/04/23
AB The  oxygen  required  by  tissues  for  aerobic  metabolism  is  supplied  by  the  circulating  mass  of  mature  erythrocytes  (red  blood  cells).  The  circulating  red  blood  cell  population  is  continually  renewed  by  the  erythroid  precursor  cells  in  the  marrow,  under  the  control  of  both  humoral  and  cellular  growth  factors.  This  cycle  of  normal  erythropoiesis  is  a  carefully  regulated  process.  Oxygen  sensors  within  the  kidney  detect  minute  changes  in  the  amount  of  oxygen  available  to  tissue  and  by  releasing  erythropoietin  are  able  to  adjust  erythropoiesis  to  match  tissue  requirements.  Thus,  normal  erythropoiesis  is  best  described  according  to  its  major  components,  including  red  blood  cell  structure,  function,  and  turnover;  the  capacity  of  the  erythroid  marrow  to  produce  new  red  blood  cells;  and  growth  factor  regulation.