RT Book, Section
A1 Seldin, David C.
A1 Skinner, Martha
A2 Longo, Dan L.
SR Print(0)
ID 1128354490
T1 AMYLOIDOSIS
T2 Harrison's Hematology and Oncology, 2e
YR 2013
FD 2013
PB McGraw-Hill Education
PP New York, NY
SN 9780071814904
LK hemonc.mhmedical.com/content.aspx?aid=1128354490
RD 2024/04/25
AB Amyloidosis  is  the  term  for  diseases  caused  by  the  extracellular  deposition  of  insoluble  polymeric  protein  fibrils  in  tissues  and  organs.  These  diseases  are  a  subset  of  a  growing  group  of  disorders  attributed  to  misfolding  of  proteins.  Among  these  are  Alzheimer's  disease  and  other  neurodegenerative  diseases;  transmissible  prion  diseases;  and  genetic  diseases  caused  by  mutations  that  lead  to  misfolding,  aggregation,  and  protein  loss  of  function,  such  as  certain  of  the  cystic  fibrosis  mutations.  Amyloid  fibrils  share  a  common  β-pleated  sheet  structural  conformation  that  confers  unique  staining  properties.  The  term  amyloid  was  coined  by  the  pathologist  Rudolf  Virchow  around  1854,  who  thought  such  deposits  were  cellulose-like  under  the  microscope.