RT Book, Section
A1 Morin, Pat J.
A1 Trent, Jeffrey M.
A1 Collins, Francis S.
A1 Vogelstein, Bert
A2 Longo, Dan L.
SR Print(0)
ID 1128355364
T1 CANCER GENETICS
T2 Harrison's Hematology and Oncology, 2e
YR 2013
FD 2013
PB McGraw-Hill Education
PP New York, NY
SN 9780071814904
LK hemonc.mhmedical.com/content.aspx?aid=1128355364
RD 2024/04/19
AB Cancer  arises  through  a  series  of  somatic  alterations  in  DNA  that  result  in  unrestrained  cellular  proliferation.  Most  of  these  alterations  involve  actual  sequence  changes  in  DNA  (i.e.,  mutations).  They  may  originate  as  a  consequence  of  random  replication  errors,  exposure  to  carcinogens  (e.g.,  radiation),  or  faulty  DNA  repair  processes.  While  most  cancers  arise  sporadically,  familial  clustering  of  cancers  occurs  in  certain  families  that  carry  a  germline  mutation  in  a  cancer  gene.