RT Book, Section
A1 Pichun, Mauricio Burotto
A1 Fojo, Tito
A2 Boyiadzis, Michael M.
A2 Frame, James N.
A2 Kohler, David R.
A2 Fojo, Tito
SR Print(0)
ID 1128367700
T1 Oncologic Emergencies
T2 Hematology-Oncology Therapy, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071637893
LK hemonc.mhmedical.com/content.aspx?aid=1128367700
RD 2024/04/24
AB EtiologyTable  Graphic  Jump  Location|Download  (.pdf)|PrintEtiologyLifetime  incidence  of  SCC  in  cancer  patients:1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,361–6%Median  overall  survival  of  patients  with  SCC:3–16  monthsSCC  as  the  initial  manifestation  of  cancer:20–30%  of  all  cases  of  SCCSCC  as  the  initial  manifestation  of  cancer:Lung  cancerCancer  of  unknown  primaryNon-Hodgkin  lymphomaMultiple  myelomaSCC  distribution  along  spine:  Thoracic  spine:  Lumbar  spine:  Cervical  spine:60–80%15–30%4–13%Sites  of  InvolvementPercentage  of  SCCHistology  (%  Among  All  Cases)Extradural  metastases:✫90–95Prostate  cancer  (15–20%)Breast  cancer  (15–20%)Lung  cancer  (15–20%)Non-Hodgkin  lymphoma  (5–10%)Multiple  myeloma  (5–10%)Renal  cancer  (5–10%)Intradural  masses:5–10MeningiomaNerve  sheath  tumorsLarge  leptomeningeal  metastasesTransforaminal  progression  of  paravertebral  tumor:UncommonLymphomasNeuroblastomasPrimary  hematogenous  seeding  to  epidural  space:Rare  ✫The  most  common  mechanisms  are:  Direct  extension  into  the  epidural  space  of  a  hematogenous  metastasis  to  a  vertebral  bodyPathologic  fracture  of  a  vertebral  body  infiltrated  by  a  metastatic  deposit  resulting  in  cord  injury  by  a  bone  fragment  or  spinal  instability