RT Book, Section
A1 Rengan, Ramesh
A1 Stripp, Diana C.
A1 Glatstein, Eli
A2 Boyiadzis, Michael M.
A2 Frame, James N.
A2 Kohler, David R.
A2 Fojo, Tito
SR Print(0)
ID 1128367878
T1 Radiation Complications
T2 Hematology-Oncology Therapy, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071637893
LK hemonc.mhmedical.com/content.aspx?aid=1128367878
RD 2024/04/24
AB The  ultimate  determinant  of  the  efficacy  of  any  anticancer  therapy  is  the  therapeutic  ratio.  The  therapeutic  ratio  for  a  given  dose  of  radiation  therapy  (RT)  is  defined  as  the  ratio  of  the  tumor  control  rate  to  the  observed  normal  tissue  toxicity.  The  larger  this  ratio  is,  the  better  tolerated  the  treatment  is  at  any  given  dose.  Indeed,  the  “definitive”  therapeutic  dose  for  most  solid  tumors  has  been  determined  by  the  clinically  observed  radiotolerance  of  the  surrounding  normal  tissues,  not  the  dose  required  for  tumor  sterilization.  Therefore,  with  an  understanding  of  acute  and  chronic  toxicities  of  radiation,  one  can  potentially  improve  the  therapeutic  ratio  through  effective  intervention