RT Book, Section
A1 Frame, James N.
A1 Bartholomew, John R.
A2 Boyiadzis, Michael M.
A2 Frame, James N.
A2 Kohler, David R.
A2 Fojo, Tito
SR Print(0)
ID 1128368100
T1 Heparin-Induced Thrombocytopenia
T2 Hematology-Oncology Therapy, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071637893
LK hemonc.mhmedical.com/content.aspx?aid=1128368100
RD 2024/04/20
AB Heparin-induced  thrombocytopenia  is  a  prothrombotic  disorder  mediated  by  IgG  antibodies  that  bind  to  conformational  epitopes  on  PF4  when  it  is  complexed  with  heparin.  Typically,  the  platelet  counts  are  only  moderately  reduced.  Occasionally  patients  do  not  have  thrombocytopenia,  but  their  platelet  counts  decrease  by  50%  from  pretreatment  levels  Kelton  JG  et  al.  N  Engl  J  Med  2013;368:737–744