RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Prchal, Josef T.
A1 Levi, Marcel M.
A1 Burns, Linda J.
A1 Armitage, James O.
SR Print(0)
ID 1133362479
T1 Folate, Cobalamin, and Megaloblastic Anemias
T2 Williams Manual of Hematology, 9e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259642470
LK hemonc.mhmedical.com/content.aspx?aid=1133362479
RD 2024/04/24
AB These  disorders  are  caused  by  impaired  synthesis  of  DNA.They  most  commonly  result  from  folate  or  cobalamin  (vitamin  B12)  deficiency.Characteristics  are  megaloblastic  cells,  typically  present  in  the  erythroid  series  as  large  cells  with  immature-appearing  nuclei  but  with  increasing  hemoglobinization  of  the  cytoplasm—often  referred  to  as  nuclear-cytoplasmic  asynchrony.Megaloblastic  granulocytic  cells  have  large  size.  Giant  band  neutrophils  are  a  feature  in  the  marrow  with  hypersegmented  neutrophils  in  the  marrow  and  blood.  Megakaryocytes  may  be  abnormally  large  with  nuclear  abnormalities.