RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Prchal, Josef T.
A1 Levi, Marcel M.
A1 Burns, Linda J.
A1 Armitage, James O.
SR Print(0)
ID 1133362702
T1 Erythrocyte Membrane Disorders
T2 Williams Manual of Hematology, 9e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259642470
LK hemonc.mhmedical.com/content.aspx?aid=1133362702
RD 2024/04/19
AB The  erythrocyte  membrane  plays  a  critical  role  in  the  maintenance  of  the  biconcave  shape  and  integrity  of  the  red  cell.It  provides  flexibility,  durability,  and  tensile  strength,  enabling  erythrocytes  to  undergo  extensive  and  repeated  distortion  during  their  passage  through  the  microvasculature.It  consists  of  a  lipid  bilayer  with  embedded  transmembrane  proteins  and  an  underlying  membrane  protein  skeleton  that  is  attached  to  the  bilayer  via  linker  proteins.The  integrity  of  the  membrane  relies  on  vertical  interactions  between  the  skeleton  and  the  bilayer,  as  well  as  on  horizontal  interactions  within  the  membrane  skeletal  network.