RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Prchal, Josef T.
A1 Levi, Marcel M.
A1 Burns, Linda J.
A1 Armitage, James O.
SR Print(0)
ID 1133362924
T1 Methemoglobinemia and Other Dyshemoglobinemias
T2 Williams Manual of Hematology, 9e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259642470
LK hemonc.mhmedical.com/content.aspx?aid=1133362924
RD 2024/04/20
AB Increased  methemoglobin  from  a  baseline  of  less  than  1%  occurs  due  to  oxidation  of  ferro  to  ferric  iron  of  hemoglobin  from  environmental  agents  or  due  to  underlying  germline  mutations  causing  diminished  reduction  of  methemoglobin  to  hemoglobin.  Cyanosis  is  almost  always  seen.Dyshemoglobinemia  is  a  term  used  for  modified  hemoglobins  (eg,  methemoglobin,  carboxyhemoglobin,  nitrosohemoglobin,  and  sulfhemoglobin)  that  are  associated  with  normal  amino  acid  sequence  of  hemoglobin  tetramers;  however  in  M  hemoglobins  the  globins  are  mutated  changing  amino  acid  in  hemoglobin  tetramers.  They  can  result  in  varying  degree  of  clinical  manifestations.