RT Book, Section A1 Lichtman, Marshall A. A1 Kaushansky, Kenneth A1 Prchal, Josef T. A1 Levi, Marcel M. A1 Burns, Linda J. A1 Armitage, James O. SR Print(0) ID 1133363108 T1 Cryopathic Hemolytic Anemia T2 Williams Manual of Hematology, 9e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259642470 LK hemonc.mhmedical.com/content.aspx?aid=1133363108 RD 2024/10/09 AB This type of anemia is caused by autoantibodies that bind red cells best at temperatures below 37°C, usually below 31°C.It is mediated through two major types of “cold antibody”: cold agglutinins and Donath-Landsteiner antibodies.Clinical features vary considerably, but in both types, the complement system plays a major role in red cell destruction.