RT Book, Section A1 Lichtman, Marshall A. A1 Kaushansky, Kenneth A1 Prchal, Josef T. A1 Levi, Marcel M. A1 Burns, Linda J. A1 Armitage, James O. SR Print(0) ID 1133363131 T1 Drug-Induced Hemolytic Anemia T2 Williams Manual of Hematology, 9e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259642470 LK hemonc.mhmedical.com/content.aspx?aid=1133363131 RD 2024/10/09 AB Three mechanisms of drug-related immunologic injury to red cells are defined:— Hapten/drug adsorption involving drug-dependent antibodies— Ternary complex formation involving drug-dependent antibodies— Induction of autoantibodies that react with red cells in the absence of the inciting drugDrug-related nonimmunologic protein adsorption may also result in a positive direct antiglobulin test without red cell injury.Table 24–1 lists the drugs implicated in the production of a positive direct antiglobulin test and accelerated red cell destruction.Table 24–2 summarizes the four mechanisms of drug-induced immune interaction with the red cell surface.