RT Book, Section A1 Lichtman, Marshall A. A1 Kaushansky, Kenneth A1 Prchal, Josef T. A1 Levi, Marcel M. A1 Burns, Linda J. A1 Armitage, James O. SR Print(0) ID 1133363973 T1 Polycythemia Vera T2 Williams Manual of Hematology, 9e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259642470 LK hemonc.mhmedical.com/content.aspx?aid=1133363973 RD 2024/03/28 AB Polycythemia vera (PV) is a clonal disorder arising from somatic mutations of a multipotential hematopoietic cell, in which blood cell production, notably erythropoiesis, is increased independent of cytokine regulation. This results in exaggerated proliferation and accumulation of erythrocytic, and often also granulocytic, and megakaryocytic cells. PV is one of the myeloproliferative neoplasms (MPN), along with essential thrombocythemia (ET), primary myelofibrosis (MF), and chronic myelogenous leukemia (CML).Three myeloproliferative neoplasms (PV, ET, MF) share a common molecular abnormality/marker, the JAK2 kinase V617F mutation. CML stands alone; it has a different molecular marker (bcr/abl, due to a reciprocal translocation between chromosome 9 and chromosome 22, t(9;22)(q34;q11)).