RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Prchal, Josef T.
A1 Levi, Marcel M.
A1 Burns, Linda J.
A1 Armitage, James O.
SR Print(0)
ID 1133364294
T1 Classification and Clinical Manifestations of Polyclonal Lymphocyte and Plasma Cell Disorders
T2 Williams Manual of Hematology, 9e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259642470
LK hemonc.mhmedical.com/content.aspx?aid=1133364294
RD 2024/04/23
AB Polyclonal  lymphocyte  and  plasma  cell  disorders  can  be  classified  into  two  major  groups:  primary  disorders  and  acquired  disorders.  See  Table  48–1.—  Primary  disorders  result  from  defects  intrinsic  to  B  lymphocytes  (eg,  X-linked  agammaglobulinemia),  T  lymphocytes  (eg,  congenital  thymic  aplasia),  and/or  natural  killer  cells,  the  latter  usually  coupled  with  a  B-  or  T-cell  deficiency  (eg,  interleukin-7  receptor  α-chain  deficiency)  (see  Chap.  50).—  Acquired  disorders  result  from  physiologic  or  pathophysiologic  responses  to  extrinsic  factors,  usually  infectious  agents  (eg,  Epstein-Barr  virus  or  human  immunodeficiency  virus  infection)  (see  Chaps.  51  and  52).Monoclonal  (neoplastic)  lymphocyte  and  plasma  cell  disorders  are  discussed  in  Part  VIII  and  are  classified  in  Chap.  53.  Specific  neoplastic  disorders  are  discussed  in  Chaps.  54  to  71.Lymphocyte  disorders  can  have  clinical  manifestations  that  are  not  restricted  to  cells  of  the  immune  system  (eg,  leprosy  or  systemic  lupus  erythematosus).In  some  cases,  classification  is  influenced  by  disease  manifestations:—  Diseases  caused  by  production  of  pathologic  autoantibodies  (eg,  autoimmune  hemolytic  disease  [see  Chap.  22–24]  and  autoimmune  thrombocytopenia  [see  Chap.  73]).—  Diseases  caused  by  excess  production  of  lymphocyte  cytokines  (eg,  chronic  inflammatory  disorders).