RT Book, Section A1 Lichtman, Marshall A. A1 Kaushansky, Kenneth A1 Prchal, Josef T. A1 Levi, Marcel M. A1 Burns, Linda J. A1 Armitage, James O. SR Print(0) ID 1133364294 T1 Classification and Clinical Manifestations of Polyclonal Lymphocyte and Plasma Cell Disorders T2 Williams Manual of Hematology, 9e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259642470 LK hemonc.mhmedical.com/content.aspx?aid=1133364294 RD 2024/10/03 AB Polyclonal lymphocyte and plasma cell disorders can be classified into two major groups: primary disorders and acquired disorders. See Table 48–1.— Primary disorders result from defects intrinsic to B lymphocytes (eg, X-linked agammaglobulinemia), T lymphocytes (eg, congenital thymic aplasia), and/or natural killer cells, the latter usually coupled with a B- or T-cell deficiency (eg, interleukin-7 receptor α-chain deficiency) (see Chap. 50).— Acquired disorders result from physiologic or pathophysiologic responses to extrinsic factors, usually infectious agents (eg, Epstein-Barr virus or human immunodeficiency virus infection) (see Chaps. 51 and 52).Monoclonal (neoplastic) lymphocyte and plasma cell disorders are discussed in Part VIII and are classified in Chap. 53. Specific neoplastic disorders are discussed in Chaps. 54 to 71.Lymphocyte disorders can have clinical manifestations that are not restricted to cells of the immune system (eg, leprosy or systemic lupus erythematosus).In some cases, classification is influenced by disease manifestations:— Diseases caused by production of pathologic autoantibodies (eg, autoimmune hemolytic disease [see Chap. 22–24] and autoimmune thrombocytopenia [see Chap. 73]).— Diseases caused by excess production of lymphocyte cytokines (eg, chronic inflammatory disorders).