RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Prchal, Josef T.
A1 Levi, Marcel M.
A1 Burns, Linda J.
A1 Armitage, James O.
SR Print(0)
ID 1133364718
T1 The Acute Lymphocytic Leukemias
T2 Williams Manual of Hematology, 9e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259642470
LK hemonc.mhmedical.com/content.aspx?aid=1133364718
RD 2024/09/18
AB Acute  lymphocytic  (synonym:  lymphoblastic)  leukemia  (ALL)  is  a  neoplastic  disease  of  immature  lymphocytes  or  lymphocyte  progenitor  cells  of  either  the  B-  or  T-cell  lineage.The  immune  phenotype  of  the  leukemia  cells  reflects  the  cell  lineage  and  differentiation  stage  of  the  transformed  clone.At  diagnosis,  the  leukemia  cells  typically  have  replaced  normal  cells  in  the  marrow  and  have  disseminated  to  various  extramedullary  sites,  accounting  for  many  of  the  clinical  manifestations.Both  immunologic  and  genetic  subgroups  have  therapeutic  implications.Survival  for  patients  with  ALL  has  improved  with  nearly  90%  of  children  and  40%  of  adults  achieving  long-term  disease-free  survival,  although  patients  older  than  60  years  of  age  still  have  a  poor  prognosis.