RT Book, Section A1 Lichtman, Marshall A. A1 Kaushansky, Kenneth A1 Prchal, Josef T. A1 Levi, Marcel M. A1 Burns, Linda J. A1 Armitage, James O. SR Print(0) ID 1133365107 T1 Follicular Lymphoma T2 Williams Manual of Hematology, 9e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259642470 LK hemonc.mhmedical.com/content.aspx?aid=1133365107 RD 2024/03/29 AB Follicular lymphoma (FL) is an indolent lymphoid neoplasm that is derived from mutated germinal center B cells and exhibits a nodular or follicular histologic pattern.— FL is typically composed of a mixture of small, cleaved follicle center cells referred to as centrocytes and large noncleaved follicular center cells referred to as centroblasts.— The disease has masqueraded under multiple previous monikers, including “nodular lymphoma” in the Rappaport classification and “follicle center cell lymphoma” in the Working Formulation.FL accounts for approximately 20% to 25% of adult non-Hodgkin lymphomas (NHLs) in the United States, with an annual incidence of approximately 14,000 new cases per year.The disease is uncommon in persons younger than age 20 years. Pediatric cases appear to represent a separate disease entity that is typically localized, lacks the translocation 14;18 and BCL-2 expression, and has a very good prognosis.