RT Book, Section A1 Aster, Jon C. A1 Bunn, H. Franklin SR Print(0) ID 1175062582 T1 Hemostasis and Thrombosis: Introduction T2 Pathophysiology of Blood Disorders, 2e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9781259642067 LK hemonc.mhmedical.com/content.aspx?aid=1175062582 RD 2024/10/09 AB Hemostasis commands special attention among both physicians and investigators. The importance and appeal of this discipline rests on exciting scientific advances as well as its obvious clinical relevance. The mechanisms underlying the initiation and control of blood coagulation constitute an elaborate and beautifully integrated system of cellular and molecular interactions that fulfill a biological function of crucial importance. As summarized in Chapter 1, the circulation of blood cells and plasma through the vascular tree is essential for providing the body’s organs and tissues with nutrients and oxygen and for defense against infection and inflammation. Platelets, endothelial cells, and coagulation proteins cooperate in a complex and dynamic way to repair leaks in the vasculature and protect against hemorrhage in a high-pressure circulatory system.