RT Book, Section A1 Aster, Jon C. A1 Bunn, H. Franklin SR Print(0) ID 1175062587 T1 White Blood Cell Disorders: Introduction T2 Pathophysiology of Blood Disorders, 2e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9781259642067 LK hemonc.mhmedical.com/content.aspx?aid=1175062587 RD 2024/03/28 AB These drawings, showing phagocytic white blood cells (leukocytes) from various species, are those of Elie Metchnikoff, an early pioneer in the field of immunity who shared the Nobel Prize in 1908 with Paul Ehrlich, another founding father of modern immunology. Metchnikoff was the first to recognize the ability of leukocytes to move toward pathogens (chemotaxis) and subsequently surround and kill them (ideas that were highly controversial at the time). Because of their roles as both sentinels and effectors of the innate and adaptive immune system, leukocytes are frequently measured and monitored in clinical practice. An increased white blood cell count (leukocytosis) is one of the most common signs of infectious and inflammatory diseases.