RT Book, Section A1 Morin, Pat J. A1 Trent, Jeffrey M. A1 Collins, Francis S. A1 Vogelstein, Bert A2 Longo, Dan L. SR Print(0) ID 1135228240 T1 Cancer Genetics T2 Harrison's Hematology and Oncology, 3e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9781259835834 LK hemonc.mhmedical.com/content.aspx?aid=1135228240 RD 2024/10/06 AB Cancer arises through a series of somatic alterations in DNA that result in unrestrained cellular proliferation. Most of these alterations involve actual sequence changes in DNA (i.e., mutations). They may originate as a consequence of random replication errors, exposure to carcinogens (e.g., radiation), or faulty DNA repair processes. While most cancers arise sporadically, familial clustering of cancers occurs in certain families that carry a germline mutation in a cancer gene.