RT Book, Section
A1 Giacomini, Kathleen M.
A1 Sugiyama, Yuichi
A2 Brunton, Laurence L.
A2 Hilal-Dandan, Randa
A2 Knollmann, Björn C.
SR Print(0)
ID 1162533244
T1 Membrane Transporters and Drug Response
T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259584732
LK hemonc.mhmedical.com/content.aspx?aid=1162533244
RD 2024/04/15
AB Membrane  transport  proteins  are  present  in  all  organisms.  These  proteins  control  the  influx  of  essential  nutrients  and  ions  and  the  efflux  of  cellular  waste,  environmental  toxins,  drugs,  and  other  xenobiotics  (Figure  5–1).  Consistent  with  their  critical  roles  in  cellular  homeostasis,  about  2000  genes  in  the  human  genome,  ∼7%  of  the  total  number  of  genes,  code  for  transporters  or  transporter-related  proteins.  The  functions  of  membrane  transporters  may  be  facilitated  (equilibrative,  not  requiring  energy)  or  active  (requiring  energy).  In  considering  the  transport  of  drugs,  pharmacologists  generally  focus  on  transporters  from  two  major  superfamilies,  ABC  and  SLC  transporters  (Nigam,  2015).