RT Book, Section
A1 Yoon, Sam S.
A1 Pollock, Raphael E.
A2 Morita, Shane Y.
A2 Balch, Charles M.
A2 Klimberg, V. Suzanne
A2 Pawlik, Timothy M.
A2 Posner, Mitchell C.
A2 Tanabe, Kenneth K.
SR Print(0)
ID 1145756508
T1 Soft Tissue Sarcoma: Epidemiology, Predisposing and Genetic Factors, and Staging
T2 Textbook of Complex General Surgical Oncology
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071793315
LK hemonc.mhmedical.com/content.aspx?aid=1145756508
RD 2024/04/25
AB Soft  tissue  sarcomas  (STS)  are  comprised  of  malignant  tumors  which  arise  from  tissues  of  mesodermal  origin  (e.g.,  fat,  muscle,  connective  tissue,  vessels)  excluding  bone  and  cartilage.  There  are  over  50  different  histologic  subtypes  of  STS.1  In  addition,  malignant  tumors  of  peripheral  nerve  sheaths  are  usually  classified  at  STS  despite  being  ectodermal  in  origin.  Gastrointestinal  stromal  tumors  (GISTs)  are  derived  from  the  interstitial  cells  of  Cajal,  which  have  neural  and  smooth  muscle  features,  and  thus  GISTs  are  also  considered  STS.2  The  most  common  subtypes  include  liposarcoma,  leiomyosarcoma,  undifferentiated  pleomorphic  sarcoma  (UPS,  formerly  called  malignant  fibrous  histiocytoma),  GIST,  and  synovial  sarcoma.  The  biological  heterogeneity  of  the  different  STS  subtypes  is  likely  as  great  as  that  of  all  adenocarcinomas  (e.g.,  lung,  colorectal,  breast,  prostate,  and  other  adenocarcinomas),  but  STS  are  much  less  common,  and  thus  they  are  all  grouped  together  for  practical  purposes.  A  subsequent  chapter  is  devoted  to  the  description  of  the  different  STS  histological  subtypes.