RT Book, Section A1 Hansraj, Natasha A1 Olson, John A. A1 Turner, Douglas J. A2 Morita, Shane Y. A2 Balch, Charles M. A2 Klimberg, V. Suzanne A2 Pawlik, Timothy M. A2 Posner, Mitchell C. A2 Tanabe, Kenneth K. SR Print(0) ID 1145757770 T1 Parathyroid Carcinoma T2 Textbook of Complex General Surgical Oncology YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9780071793315 LK hemonc.mhmedical.com/content.aspx?aid=1145757770 RD 2024/04/25 AB Parathyroid carcinoma is a rare malignant neoplasm of the parathyroid causing parathyroid hormone (PTH)–dependent hypercalcemia. Diagnosis is difficult so a high level of suspicion must be maintained, particularly in patients with markedly elevated serum calcium levels, local symptoms, and elevated PTH levels. Presence of these or clinical suspicion at surgery should allow consideration for a more aggressive surgical resection at the initial surgery. In this chapter we review current information on genetics and features of parathyroid carcinoma, and treatment options in the perioperative period.