RT Book, Section
A1 Holt, Shelby
A1 Barron, Alison Unzeitig
A1 Nwariaku, Fiemu
A2 Morita, Shane Y.
A2 Balch, Charles M.
A2 Klimberg, V. Suzanne
A2 Pawlik, Timothy M.
A2 Posner, Mitchell C.
A2 Tanabe, Kenneth K.
SR Print(0)
ID 1145757799
T1 Multiple Endocrine Neoplasia Type 1
T2 Textbook of Complex General Surgical Oncology
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071793315
LK hemonc.mhmedical.com/content.aspx?aid=1145757799
RD 2024/04/18
AB The  multiple  endocrine  neoplasia  type  1  (MEN1)  syndrome  was  initially  described  in  1954  as  Wermer’s  syndrome.  Dr  Paul  Wermer  reported  on  a  syndrome  in  which  adenomatosis  of  the  anterior  pituitary,  parathyroid,  and  pancreatic  islets  was  observed  in  a  family  in  which  the  father  and  four  of  nine  siblings  were  affected.1  He  postulated  that  this  syndrome  was  likely  inherited  as  an  autosomal  dominant  disease  and  that  these  patients  commonly  also  suffered  from  ulcers  of  the  stomach  and  duodenum.  It  is  now  widely  known  that  MEN1  consists  of  a  constellation  of  multiglandular  parathyroid  disease,  neuroendocrine  tumors  of  the  gastroenteropancreatic  system,  anterior  pituitary  adenomas,  and  other  associated  nonendocrine  manifestations  such  as  facial  angiofibromas.