RT Book, Section
A1 Balentine, Courtney
A1 Sippel, Rebecca S.
A1 Chen, Herbert
A1 Schneider, David F.
A2 Morita, Shane Y.
A2 Balch, Charles M.
A2 Klimberg, V. Suzanne
A2 Pawlik, Timothy M.
A2 Posner, Mitchell C.
A2 Tanabe, Kenneth K.
SR Print(0)
ID 1145758007
T1 Pheochromocytoma
T2 Textbook of Complex General Surgical Oncology
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071793315
LK hemonc.mhmedical.com/content.aspx?aid=1145758007
RD 2024/04/19
AB Pheochromocytomas  (PCCs)  and  paragangliomas  (PGLs)  arise  from  chromafin  cells  originating  in  the  neural  crest,  and  can  develop  in  any  location  containing  sympathetic  or  parasympathetic  tissue.  Although  the  terminology  is  not  completely  standardized,  PCC  typically  refers  to  tumors  of  adrenal  origin  while  PGL  describes  lesions  found  outside  the  adrenal  gland.  While  most  PCC  and  PGL  are  benign,  malignant  disease  does  occur  and  is  distinguished  by  behavior  such  as  metastasis  and  invasion  into  other  structures.  Identifying  benign  disease  with  potential  to  become  malignant  is  exceedingly  difficult  as  there  is  currently  no  reliable  gene  signature  or  histologic  feature  that  clearly  identifies  malignancy.  Even  more  importantly,  metastasis  can  occur  15  to  20  years  after  resection  of  apparently  benign  disease,  and  this  makes  it  difficult  to  accurately  study  PCC  and  predict  malignancy.