RT Book, Section
A1 Goff, Stephanie L.
A1 Hughes, Marybeth S.
A2 Morita, Shane Y.
A2 Balch, Charles M.
A2 Klimberg, V. Suzanne
A2 Pawlik, Timothy M.
A2 Posner, Mitchell C.
A2 Tanabe, Kenneth K.
SR Print(0)
ID 1145758546
T1 Ectopic ACTH Syndrome
T2 Textbook of Complex General Surgical Oncology
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071793315
LK hemonc.mhmedical.com/content.aspx?aid=1145758546
RD 2024/04/19
AB Cushing’s  syndrome  is  a  symptomatic  manifestation  of  a  wide  variety  of  disease  processes  culminating  in  hypercortisolism,  only  a  few  of  which,  including  ectopic  ACTH  syndrome  (EAS),  necessitate  the  attention  of  a  surgical  oncologist.1  In  the  classical  setting  of  EAS,  the  diagnosis  begins  under  the  supervision  of  an  endocrinologist,  and  the  careful  application  of  a  diagnostic  algorithm  of  laboratory  testing,  imaging,  and/or  interventional  procedures  often  helps  identify  a  source.2  However,  EAS  can  also  present  in  a  paraneoplastic  fashion  in  a  patient  with  a  known  malignancy,  and  surgical  oncologists  may  be  called  upon  to  identify  a  potential  source.  This  chapter  will  briefly  review  the  physiology  of  the  hypothalamic-pituitary-adrenal  (HPA)  axis  and  Cushing’s  syndrome,  discuss  the  diagnosis  of  EAS  and  its  descriptive  classifiers,  and  outline  management  strategies  for  the  care  of  patients  with  EAS.